Japan JSPS Program: "Polymeric Micelles: A New Molecular Architecture for in Vivo Drug Carriers"

该奖项将提供补充支持，使犹他大学的Glen Kuan博士能够在日本东京的东京女子医学院生物医学工程研究所与Teruo Okano博士进行为期16个月的合作研究。权相权和冈野将利用权相权在聚合物微球和受控释放系统方面的知识，对聚合物胶束作为阿霉素药物载体进行研究。胶体药物载体，如聚合物微球、脂质体和可溶性聚合物载体，已经被开发出来以提高体内药物作用的效率。然而，这些系统的缺点使它们无法提高许多药物的治疗指数。日本已开发出一种由聚合物胶束合成的新型药物载体，并已证明在不存在其他方法所涉及的问题的情况下提高了阿霉素的效率。在日本，聚合物胶束给药系统的前沿研究进展迅速，冈野的实验室是最好的实验室之一。权相权在药剂学和涉及蛋白质和多肽的受控药物输送系统方面的知识补充了冈野在合成聚合物胶束方面的专业知识。这项合作研究将为权相成提供日本在新型聚合物合成方法和生物材料作为药物载体的应用方面的第一手知识。

This award will provide supplementary support to enable Dr. Glen Kwon of the University of Utah to conduct collaborative research with Dr. Teruo Okano for 16 months at the Institute of Biomedical Engineering, Tokyo Women's Medical College, in Tokyo, Japan. Kwon and Okano will apply Kwon's knowledge of polymeric microspheres and controlled delivery systems to conduct research on polymeric micelles as a drug carrier for adriamycin. Colloidal drug carriers, such as polymeric microspheres, liposomes, and soluble polymeric carriers, have been developed to increase the efficacy of drug action in vivo. The disadvantages of these systems, however, preclude their ability to increase the therapeutic index of many drugs. A new drug carrier synthesized of polymeric micelles has been developed in Japan and has proven to increase the efficiency of adriamycin without the problems associated with the other methods. Leading-edge research on polymeric micelle drug delivery systems is advancing quickly in Japan, and Okano's laboratory is one of the best. Kwon's knowledge of pharmaceutics and controlled drug delivery systems involving proteins and polypeptides complements Okano's expertise in synthesizing polymeric micelles. This collaborative research will provide Kwon with first-hand knowledge of the Japanese approach to novel polymer synthesis methods and applications of biomaterials as drug carriers.