Thermodynamics of Site-Specific Binding Processes in Biological Macromolecules

本研究的目的是阐明多位点大分子单独结合的物理化学性质，并为描述位点特异性能量学发展一种新的热力学理论。迪塞拉博士将探索单个位点相互耦合的方式，以及它们的性质与大分子整体的性质的关系，以及局部形成的位点-位点相互作用的协同模式如何转化为大分子整体的全局合作行为。

The aim of this research program is to elucidate the physico- chemical properties of individual binding of multi-site macromolecules and to develop a new thermodynamic theory for the description of site-specific energetics. Dr. Di Cera will explore the way individual sites are coupled to each other, and the way their properties relate to those of the macromolecule as a whole and how the cooperativity patterns arising locally form site-site interactions translate in the global cooperative behavior of the macromolecule as a whole.