Site-specific protein functionalisation at diselenides via photocatalysis

通过光催化对二硒化物进行位点特异性蛋白质功能化

• 批准号: DP230100186
• 负责人: Prof Richard Payne
• 金额: $ 37.88万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-23 至 2026-01-22
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100186
• 关键词: Site; specific; protein; functionalisation; diselenides

This project aims to develop a new photocatalytic reaction for the on demand functionalisation of proteins. The synthetic methodology will solve a major technological gap in the field by enabling efficient access to proteins with defined modifications at specific locations. Functionalised proteins generated in the project will underpin a detailed understanding of how specific modifications influence the structure and function of several important proteins. The project will generate significant new knowledge in the fields of chemistry and biology and will foster interdisciplinary collaboration, nationally and internationally. The breakthrough technology also has the potential to benefit Australia’s biotechnology sector.

该项目旨在开发一种新的光催化反应，用于蛋白质的按需功能化。这种合成方法将解决该领域的一个主要技术空白，通过在特定位置通过定义的修饰来有效地获取蛋白质。该项目中产生的功能化蛋白质将为详细了解特定修饰如何影响几种重要蛋白质的结构和功能奠定基础。该项目将在化学和生物领域产生重要的新知识，并将促进国内和国际的跨学科合作。这项突破性技术也有可能造福澳大利亚的生物技术行业。