Site-specific protein functionalisation at diselenides via photocatalysis
Site-specific protein functionalisation at diselenides via photocatalysis
批准号:
DP230100186
负责人:
Prof Richard Payne
金额:
$37.88万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2023
资助国家:
澳大利亚
项目状态:
未结题
起止时间:
2023-01-23 至 2026-01-22
中文摘要
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英文摘要
This project aims to develop a new photocatalytic reaction for the on demand functionalisation of proteins. The synthetic methodology will solve a major technological gap in the field by enabling efficient access to proteins with defined modifications at specific locations. Functionalised proteins generated in the project will underpin a detailed understanding of how specific modifications influence the structure and function of several important proteins. The project will generate significant new knowledge in the fields of chemistry and biology and will foster interdisciplinary collaboration, nationally and internationally. The breakthrough technology also has the potential to benefit Australia’s biotechnology sector.
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