Small Grants for Exploratory Research: Laser Atomization of Medical Solutions Used in Aerosal Therapy

这是一个关于液体表面激光雾化的SGER提案，具有潜在的医疗应用。P.I.将研究从用于气溶胶治疗的药物溶液中产生具有控制尺寸分布（1到5微米）的气溶胶的可行性，同时不损害溶液的化学完整性。初步研究表明，颗粒应在1至2微米的尺寸范围内，以最大限度地提高气溶胶治疗的效果。如果通过通风回路给药，只有原来剂量的1%到3%真正到达目标部位。长期目标是通过使用光纤输送系统将药物直接雾化在肺的大气道内。所提出的技术是美国专利权利要求“形成细颗粒”的对象。该项目将确定提出的概念的有效性，这可能在医学领域产生深远的影响，并可能导致产生超细气溶胶领域的根本性发现。

This is a SGER proposal on laser atomization from a liquid surface, with potential medical applications. The P.I. will investigate the feasibility of generating aerosols with controlled size distribution (between 1 and 5 microns) from drug solutions used in aerosol therapy, without compromising the chemical integrity of the solution. Preliminary studies indicate that the particles should be in the 1 to 2 micron size range to maximize the effectiveness of aerosol therapy. If the aerosol is administered through a ventilation circuit, only 1 to 3% of the original volume of medication actually reaches the target site. The long term objective is atomization of drugs directly within the large airways of lungs through the use of a fiber optic delivery system. The proposed technique is the object of a U.S. patent claim "Forming Fine Particles". The project will establish the validity of the proposed concept, which may have long-reaching implications in medical field and may lead to fundamental findings in the area of generating ultrafine aerosols.