Adrenomedullin: a specific regulator of venous vessel integrity

动脉和静脉显示出不同的粘附特性，这使得它们能够履行其生理作用。我们尚未了解在不同血管类型中建立和维持粘附功能的机制。我们已经发现，由肽肾上腺髓质素（ADM）发出的信号是粘附的关键介质，仅在静脉中而不是动脉中。该项目旨在利用创新模型（斑马鱼，小鼠和生物工程血管）来确定ADM控制静脉粘附的生化和机械机制。结果将提高我们对血管完整性如何在不同血管类型中控制的理解，并将通过为血管化工程组织提供信息来扩大澳大利亚研究的范围。

Arteries and veins display different adhesive properties, which enable them to fulfil their physiological roles. We are yet to understand the mechanisms that establish and maintain adhesive function in different vessel types. We have discovered that signalling by the peptide Adrenomedullin (ADM) is a key mediator of adhesion, only in veins but not arteries. This project aims to utilise innovative models (zebrafish, mouse and bioengineered vessels) to identify the biochemical and mechanical mechanisms by which ADM controls venous adhesion. Outcomes will improve our understanding on how vessel integrity is controlled across vessel types and will expand the scope of Australian research by informing efforts to vascularise engineered tissues.