COLLABORATIVE PROJECT: Molecular Studies Of Juvenile Hormone Action

该研究由细胞生物科学部和化学部联合支持，是一个跨学科项目的延续，旨在结合化学、分子生物学和生理学学科，在分子水平上了解青少年激素的作用。主要的关键包括了解昆虫基因表达激素调控的分子基础（L.M. Riddiford）， JH代谢和合成的生化和分子研究（B.D. Hammock），以及高比活性标记JHs和JHs的使用（G.D. Prestwich）。这个项目带来了三个好处。首先，科学工作是针对基因表达调控的一个基本问题，以及昆虫的变态在一个容易接近和迷人的模型系统中进行研究。其次，这项工作的实际意义可能导致新的生物特异性和环境更安全的作物害虫控制策略的发展。第三，对学生、博士后和相关研究人员的跨学科培训提高了每个实验室科学探究的质量和广度。

The proposed research, jointly supported by the Division of Cellular Biosciences and the Division of Chemistry, is the continuation of an interdisciplinary project to understand the action of juvenile hormone at the molecular level combining the disciplines of chemistry, molecular biology, and physiology. Major keys include understanding the molecular basis for hormonal regulation of gene expression in insects (L.M. Riddiford), biochemical and molecular studies of JH metabolism and synthesis (B.D. Hammock), and use of high specific activity labeled JHs and JHs (G.D. Prestwich). Three benefits result from this project. First, the scientific work is directed at a fundamental problem in regulation of gene expression, and the metamorphosis of insects in an easily accessible and fascinating model system for this study. Second, the practical implications of this work may lead to the development of new biologically specific and environmentally safer insect control strategies for crop pests. Third, the interdisciplinary training required for the students, postdoctoral fellow and faculty researchers involved enhances the quality and breadth of scientific inquiry in each laboratory.