COLLABORATIVE PROJECT: Molecular Studies Of Juvenile Hormone Action

这项拟议的研究由细胞生物科学部和化学部联合支持，是一个跨学科项目的继续，目的是在分子水平上结合化学、分子生物学和生理学学科了解保幼激素的作用。主要关键包括了解昆虫基因表达的激素调节的分子基础(L.M.Riddiford)，JH新陈代谢和合成的生化和分子研究(B.D.hammock)，以及标记JHS和JHS的高比活性标记的使用(G.D.Prestwich)。这个项目有三个好处。首先，这项科学工作是针对基因表达调控的一个基本问题，以及昆虫在本研究中易于访问和吸引人的模型系统中的变态。其次，这项工作的实际意义可能会导致开发新的生物特异性和环境安全的作物病虫害防治策略。第三，对参与其中的学生博士后研究员和教员研究人员进行的跨学科培训提高了每个实验室的科学研究的质量和广度。

The proposed research, jointly supported by the Division of Cellular Biosciences and the Division of Chemistry, is the continuation of an interdisciplinary project to understand the action of juvenile hormone at the molecular level combining the disciplines of chemistry, molecular biology, and physiology. Major keys include understanding the molecular basis for hormonal regulation of gene expression in insects (L.M. Riddiford), biochemical and molecular studies of JH metabolism and synthesis (B.D. Hammock), and use of high specific activity labeled JHs and JHs (G.D. Prestwich). Three benefits result from this project. First, the scientific work is directed at a fundamental problem in regulation of gene expression, and the metamorphosis of insects in and easily accessible and fascinating model system for this study. Second, the practical implications of this work may lead to the development of new biologically specific and environmentally safer insect control starategies for crop pest. Third, the interdiscriplinary training required for the students postdoctoral fellow and faculty researchers involved enhances the quality and breadth of scientific inquiry in each laboratory.