Luminescence Spectroelectrochemistry of Polynucleotide Complexes

这个项目是在一般地区的分析和表面 化学和生物电化学的子领域。 期间 在这六个月标准补助金的任期内，钱伯斯教授和 他的学生将采用修饰电极和激光诱导 荧光光谱电化学技术来研究 释放到溶液中的有机离子，如乙锭和 随后这些离子与双链DNA的相互作用 分子。 所得荧光光谱的分析实用性 还将评价DNA复合物。 %%% 这项研究建立在钱伯斯博士的研究成果基础上。 先前的NSF赠款，CHE-8718057，提供敏感的方法， 检测痕量的多核苷酸，并研究 它们在溶液中的传质性质。

This project is in the general area of analytical and surface chemistry and in the subfield of bioelectrochemistry. During the tenure of this six-month standard grant, Professor Chambers and his students will employ modified electrode and laser induced fluorescence spectroelectrochemistry techniques to study the release into solution of organic ions such as ethidium and the ensuing interactions of these ions with double stranded DNA molecules. The analytical utility of the resulting fluorescent DNA complexes will also be evaluated. %%% This research builds upon results obtained under Dr. Chambers' previous NSF grant, CHE-8718057, to provide sensitive methods for the detection of trace amounts of polynucleotides and to study their mass transport properties in solution.