Purchase of a Superconducting Fourier Transform NMR System

这项来自化学研究仪器项目的奖励将帮助北卡罗莱纳州立大学化学系获得一台300 MHz核磁共振光谱仪，该光谱仪将用于以下化学领域的研究调查：(1)利用手性助剂介导的不对称合成技术合成天然产物和生物活性化合物；(2)亲核盖层1,3偶极子羰基衍生物的生成和反应；(3)氟酮和甲氧基酮中电子给予和电子撤回的竞争；(4)快速发展的有机氟化学领域的理论和合成方面；(5)通过设计合成选择性氟化有机化合物的新方法，将氟原子纳入有机分子；6、有机分析化学。核磁共振光谱学是化学家用来研究分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱学对于正在进行前沿研究的化学家来说是必不可少的。这些核磁共振研究的结果在聚合物和催化以及生物学等领域都很有用。

This award from the Chemistry Research Instrumentation Program will help the Department of Chemistry at North Carolina State University acquire a 300 MHz NMR spectrometer which will be used in research investigations in the following areas of chemistry: (1) The synthesis of natural products and biologically active compounds using chiral auxiliary mediated asymmetric synthesis; (2) The generation and reactions of nucleophilic capped 1,3-dipole equivalents to carbonyl ylides; (3) The competition between electron donation and withdrawal in fluoro- and methoxyketones; (4) Theoretical and synthetic aspects of the rapidly expanding field of organofluorine chemistry; (5) The incorporation of fluorine atoms into organic molecules by devising new approaches to synthesize selectively fluorinated organic compounds; (6) Organo-analytical chemistry. Nuclear Magnetic Resonance (NMR) Spectroscopy is the most powerful tool available to the chemist for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectroscopy is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in areas such as polymers and catalysis, and in biology.