Presidential Young Investigators Award: Spectroscopic Studies of Proteins in Engineering Environments
Presidential Young Investigators Award: Spectroscopic Studies of Proteins in Engineering Environments
批准号:
9157318
负责人:
Theodore Randolph
金额:
$12.5万
依托单位:
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
1991
资助国家:
美国
项目状态:
已结题
起止时间:
1991-11-01 至 1994-04-30
中文摘要
研究将集中在两个领域。在一个领域,电子顺磁共振(EPR)将用于探测工程(即制造)环境中的蛋白质相互作用。将研究蛋白质的折叠、聚集和构象动力学。另一方面,超临界流体中自由基反应的EPR测量将提供有关超临界流体溶剂效应的基本信息。
英文摘要
Studies will be focused on two areas. In one area, Electron Paramagnetic Resonance (EPR) will be used to probe protein interactions in engineering (i.e. manufacturing) environments. Protein folding, aggregation, and conformational dynamics will be studied. In the other area, EPR measurement of free-radical reactions in supercritical fluids will provide fundamental information on supercritical fluid solvent effects.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Mechanisms of Damage to Pharmaceutical Proteins at Oil-Water Interfaces
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批准号:1133871
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项目类别:Standard Grant
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资助金额:$33.9万
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财政年份:2011
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负责人:Theodore Randolph
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依托单位:
GOALI: Aggregation of Protein Therapeutics in Aqueous Solutions
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批准号:0138595
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项目类别:Continuing Grant
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资助金额:$43.15万
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财政年份:2002
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负责人:Theodore Randolph
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依托单位:
Acquisition of a Nanoparticle Analysis Ensemble
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批准号:0079612
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项目类别:Standard Grant
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资助金额:$19.25万
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财政年份:2000
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负责人:Theodore Randolph
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依托单位:
Mechanisms for Success or Failure of Excipients and Protein-Stabilizers
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批准号:9816975
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项目类别:Standard Grant
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资助金额:$35.89万
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财政年份:1999
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负责人:Theodore Randolph
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依托单位:
Thermodynamic and Molecular Mechanisms of Protein Stabilization by Polymers During Freezing, Drying, and Rehydration: EPR and FTIR Studies
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批准号:9505301
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项目类别:Continuing Grant
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资助金额:$39.87万
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财政年份:1995
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负责人:Theodore Randolph
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依托单位:
High Pressure Effects on Protein Crystallization (Collaborative Research)
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批准号:9529288
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项目类别:Continuing Grant
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资助金额:$8.03万
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财政年份:1995
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负责人:Theodore Randolph
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依托单位:
Reactions in Supercritical Fluids: Experimental and Simulation Studies of Microscopic Phenomena
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批准号:9414759
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项目类别:Standard Grant
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资助金额:$22.36万
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财政年份:1994
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负责人:Theodore Randolph
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依托单位:
Presidential Young Investigators Award: Spectroscopic Studies of Proteins in Engineering Environments
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批准号:9496042
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项目类别:Continuing Grant
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资助金额:$20.47万
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财政年份:1993
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负责人:Theodore Randolph
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依托单位:
海外基金