Carbohydrates and Lipid Utilization in Animals

我们认为，必需脂肪酸是非常重要的 哺乳动物的冬眠和繁殖。拟议的研究将 关注脂肪酸的组成，吸收和利用， 黄腹旱獭（Marmota flaviventris）的白色脂肪组织和肝脏 并将直接评估是否有一个特定的基本 脂肪酸，亚油酸（18：2，n-6），免于β氧化， 在冬眠期间这些组织中有很大程度的 期间，10月至3月。众所周知，亚油酸是 不仅作为能源供应， 花生四烯酸的前体（20：4），也许是重要的 生殖条件和体温调节能力的变化 在冬眠期间和冬眠结束时。由于土拨鼠是哺乳动物， 这些实验的结果可以直接应用于 人类代谢紊乱几种人类病理状况 与必需脂肪酸缺乏有关。因此，委员会认为， 从这些实验中得出的结论将增进我们的知识 关于必需脂肪酸在生理过程中的作用。

We propose that essential fatty acids are very important for hibernation and reproduction in mammals. The proposed research will focus on fatty acid composition, uptake and utilization in the white adipose tissue and liver of marmots (Marmota flaviventris) by season and will directly assess if one particular essential fatty acid, linoleic acid (18:2, n-6), is spared Beta oxidation to a significant degree within these tissues during the hibernation period, October to March. It is well known that linoleic acid is very important not only as an energy supply, but also as the precursor for arachidonic acid (20:4), and perhaps is important for changes in reproductive condition and thermoregulatory capabilities during, and at the end of hibernation. As marmots are mammals, the results from these experiments may be directly applicable to the human metabolic disorders. Several human pathological conditions are associated with essential fatty acid deficiency. Consequently, conclusions drawn from these experiments will enhance our knowledge about the role of essential fatty acids in physiological processes.