Molecular Genetic Studies of Human Evolutionary History

这项拟议的研究将利用现代人之间的分子遗传变异来了解我们物种的人口学历史。这将涉及三个步骤：(1)收集世界范围内的人类线粒体和核DNA样本，(2)对样本中的个体进行大量遗传多态评分，以及(3)改进用于分析此类数据的统计方法。这里提议的试点项目将完成第一步的工作，但只开始第二步和第三步的工作。

The proposed research will use molecular genetic variation among modern humans to learn about the demographic history of our species. This will involve three steps: (1) collect a world-wide sample of human mitochondrial and nuclear DNA, (2) score the individuals in this sample for a large number genetic polymorphisms, and (3) refine the statistical methods used in analysis of such data. The pilot project proposed here will complete work on step 1, but will only begin work on steps 2 and 3.