Conference: Steroid Action on Excitable Cells: November 6, 1993; Washington D.C.

提供资金用于支付年轻科学家的旅费，并邀请与会者参加1993年11月6日在华盛顿特区举行的1993年神经科学学会作为卫星研讨会举行的类固醇对可兴奋细胞的作用会议。自20世纪60年代S提出类固醇激素的作用机制是通过基因组途径发挥作用以来，人们已经很容易接受这一观点。然而，在某些情况下，荷尔蒙可以在几秒钟到几分钟内产生效果。直到最近，这些数据一直被忽视，因为它不符合教条。现在很明显，类固醇在大脑中的作用比之前想象的要复杂得多。事实上，类固醇的作用既有基因组途径，也有非基因组途径。会议将讨论类固醇激素和甲状腺激素对可兴奋细胞的作用机制。报告将重点介绍(1)类固醇对海马区氨基酸受体的调节作用；(2)使用简单的模型系统作为检查激素对已识别的电压钳制离子电流的作用的手段；(3)新型激素受体；以及(4)类固醇的分子和生化作用。在一个快速发展和变化的领域，这些都是根本性的重要问题。这次卫星研讨会提供了一个分享关于这个主题的想法的论坛，这可能最终导致在理解类固醇激素作用机制方面的突破。

Funds are provided to defray travel costs of young scientists and invited participants to attend the Conference on Steroid Action on Excitable Cells which is to be held as a Satellite Symposium at the 1993 Society for Neuroscience on November 6, 1993 in Washington, DC. Since the 1960's, it has been readily accepted that the mechanism of steroid hormone action is by a genomic route. However, in some circumstances, hormones can have effects within seconds to minutes. Until recently, these data were ignored because it did not fit the dogma. Now it has become clear that steroid action in the brain is more complex than that previously thought. Indeed, steroid action is mediated by both genomic and non-genomic routes. The conference will address the mechanisms through which steroid hormones and thyroid hormones act on excitable cells. The presentations will highlight the exciting recent work on (1) the modulatory action of steroid on amino acid receptors in the hippocampus; (2) the use of simple model systems as means to examine the actions of hormones on identified, voltage-clamped, ion currents; (3) novel hormone receptors; and (4) the molecular and biochemical actions of steroids. These are fundamentally important questions in an field that is rapidly advancing and changing. This Satellite Symposium offers a forum for sharing of ideas on this subject which may ultimately lead to breakthroughs in understanding the mechanisms of steroid hormone action.