High Performance Imaging in Biological Research

大挑战应用小组竞赛为支持科学家和工程师组成的多学科团队提供了一种机制，以实现1992财政年度高性能计算和通信（HPCC）计划的目标。理想的提议不仅在科学上卓越，在科学和工程的关键领域具有潜在重大影响的集中问题，但也是科学和计算活动之间的重要相互作用，通常涉及数学，计算机或计算科学家；这将对正在研究的特定科学或工程问题领域或学科之外的高性能计算活动产生影响。这是一个研究和开发自动交互显微镜（AIM）的项目。AIM将结合光学显微镜和试剂化学的最新技术，以及计算机图像处理、图像分析和显示的先进技术，在高性能并行计算机上实现。这种结合将产生一种自动化、高速、互动的工具，使对活细胞和组织的新型基础生物学研究成为可能。虽然这项研究的一个里程碑将是展示AIM的概念验证，但随着新技术的出现和生物界的参与，持续的推动力将继续发展。

The Grand Challenge Application Groups competition provides one mechanism for the support of multidiscipinary teams of scientists and engineers to meet the goals of the High Performance Computing and Communications (HPCC) Initiative in Fiscal Year 1992. The ideal proposal provided not only excellence in science: focussed problem with potential for substantial impact in a critical area of science and engineering) but also significant interactions between scientific and computational activities, usually involving mathematical, computer or computational scientists, that would have impact in high-performance computational activity beyond the specific scientific or engineering problem area(s) or discipline being studied. This is a project to research and develop an Automated Interactive Microscope (AIM). The AIM will combine the latest technologies in light microscopy and reagent chemistry with advanced techniques for computerized image processing, image analysis, and display, implemented on high-performance parallel computers. This combination will produce an automated, high-speed, interactive tool that will make possible new kinds of basic biological research on living cells and tissues. While one milestone of the research will be to show the proof-of-concept of AIM, the on-going thrust will be continued development as new technologies arise and the involvement of the biological community.