Long-Range Electron Transfer Reactions in Proteins

这一奖项是科隆博士化学博士后奖学金的首次授予。这项研究将有助于更好地理解分子的重组能在长程电子转移反应中作为距离的函数。将测量与人肌红蛋白变体配位的Re(II)和Re(I)的电子转移速率。将评估电子转移距离和蛋白质中电子耦合对电子转移速率的影响。闪光猝灭和光诱导电子转移实验将被用来获得所需的速率。生物电子传递在呼吸、光合作用和免疫反应中起着重要作用。即将开展的研究将更好地洞察这些重要的反应。这些见解将有助于科学家研究人类健康的许多方面。

This award is the starter grant increment of Dr. Colon's Postdoctoral Fellowship in Chemistry. The research will result in a better understanding of the reorganizational energy of molecules as a function of distance in long range electron transfer reactions. Electron transfer rates will be measured for Re(II) and Re(I) coordinated to human myoglobin variants. The effects of distance of electron transfer and of the electronic coupling in the protein on electron transfer rates will be evaluated. Flash-quench and photoinduced electron transfer experiments will be used to obtain the desired rates. %%% Biological electron transfer plays major roles in respiration, photosynthesis, and immune response. The research to be carried out will provide a better insight into these important reactions. These insights will be helpful to scientists studying many aspcects of human health.