NSF Young Investigator/Control of Protein Secondary Structures

这项来自有机动力学项目的拨款支持了加州大学欧文分校詹姆斯·s·诺威克教授的工作。将开发一种新的策略来控制肽的二级结构，通过连接多个氨基酸链到一个作为分子支架的硬寡聚主链。分子支架将以低聚脲为基础，以迭代的方式合成。这一策略将用于制造β -片和开发小肽的分子受体。通过将肽链连接到刚性分子骨架上，可以控制肽的三维结构。主链将被设计成以平行和反平行的方式容纳几个多肽。这代表了一种控制蛋白质结构的全新方法。主链的设计非常适合于小肽受体的开发。

This grant from the Organic Dynamics Program supports the work of Professor James S. Nowick at the University of California Irvine. A new strategy will be developed for controlling peptide secondary structure by linking multiple amino acid chains to a stiff oligomeric backbone that serves as a molecular scaffold. The molecular scaffold will be based upon an oligourea that will be synthesized in an iterative fashion. This strategy will be used to create beta-sheets and to develop molecular receptors for small peptides. %%% The three dimensional structure of a peptide will be controlled by linking the peptide chain to a rigid molecular backbone. The backbone will be designed to hold several peptides in parallel and antiparallel fashions. This represents a fundamentally new approach to the control of protein structure. The design of the backbone is ideally suited for the development of receptors for small peptides.