NSF Young Investigator

叶绿体基因组利用转录和转录后水平的调控机制。该实验室开发了一种将定义突变引入衣藻叶绿体的技术，使采用遗传学方法研究叶绿体电子传递基因的翻译控制成为可能。由于mRNA的稳定性是转录后调控基因表达的一种机制，因此还将鉴定和表征影响这种稳定性的rna结合蛋白和核糖核酸酶。从叶绿体中基因表达转录后调控机制的研究中获得的信息将使我们更深入地了解地球上生命形式存在的过程。

The chloroplast genome utilizes regulatory mechanisms at both the transcriptional and post-transcriptional levels. The development of a technique to introduce defined mutations into the Chlamydomonas chloroplast by this laboratory has made it possible to take a genetic approach to studying the translational control of chloroplast electron transport genes. Since mRNA stability is one mechanism for regulating gene expression post-transcriptionally, RNA-binding proteins and ribonucleases which can affect such stability will also be identified and characterized. %%% The information resulting from this study of the mechanisms involved in post-transcriptional regulation of gene expression in the chloroplast will give greater insight into process which permits life forms to exist on this earth.