An Ultra-High Speed Magic Angle Sample Spinner for Nuclear Magnetic Resonance

这个小企业创新研究（SBIR）第一阶段项目是在分析和表面化学的一般领域，在磁共振光谱的子领域。本研究的目的是确定构建一种用于核磁共振（NMR）光谱的新型高速魔角纺丝系统的可行性。所选择的方法将使用基于气体承载系统的技术和Creare人员先前开发的技术，这些技术可以结合到各种设备中，其中一些已经商业化。目前用于核磁共振光谱的样品旋转器通常被限制在大约10千赫的转速内。一种独特的气体轴承系统，其原理成功应用于高速微型低温涡轮发电机，将用于实现40 kHz的转速。轴承将包括阻尼腔和进给孔，以提供能力和稳定性。轴承也将被配置为适应不均匀包装样品材料的不平衡。在第一阶段，一个轴将被旋转到40千赫，以证明该方法的可行性。如果成功，一个完整的超高速样品旋转器组件将在第二阶段进行演示。这项研究将测试核磁共振样品旋转器的可行性，该旋转器能够在高达40 kHz的转速下稳定运行。该装置减少了质子-质子偶极耦合引起的光谱展宽效应，显著提高了固态核磁共振的分辨能力。

This Small Business Innovation Research (SBIR) Phase I project is in the general area of analytical and surface chemistry and in the subfield of magnetic resonance spectroscopy. The objective of this research is to determine the feasibility of constructing a novel, high speed magic angle spinning system for use in nuclear magnetic resonance (NMR) spectroscopy. The approach chosen will use both technology which is based upon gas bearing systems and technologies previously developed by Creare personnel for incorporation into a variety of devices, some of which have been commercialized. Current sample spinners for NMR spectroscopy are generally limited in rotation speed to approximately 10 kHz. A unique gas bearing system based on principles successfully employed in high speed, miniature cryogenic turbomachines will be used to achieve a 40 kHz rotation speed. The bearing will incorporate damping cavities and feed orifices to provide capacity and stability. The bearing will also be configured to accommodate unbalance from nonuniform packing of sample material. In Phase I, a shaft will be spun to 40 kHz to demonstrate the feasibility of the approach. If successful, a complete ultra high speed sample spinner assembly could then be demonstrated in Phase II. %%% This research will test the feasibility of an NMR sample spinner that is capable of stable operation at rotation speeds of up to 40 kHz. This device would significantly improve the resolution capability of solid state NMR by reducing spectrum broadening effects caused by proton-proton dipolar couplings.