Purchase of a Gas Chromatograph with Mass Spectral Detector

化学研究仪器项目的这一奖项将帮助内布拉斯加州大学化学系购买一台带有质量谱检测器(GC-MS)的气相色谱仪。这种最先进的台式GC-MS对于满足化学系当前和未来的研究需求至关重要，主要是在化学系的合体组中。该仪器对该部门的研究是必不可少的，该部门包括以下领域：1)新的催化过渡金属介导的碳环化反应，2)生物有机方法，以获得新的治疗药物，(磷酸盐抑制剂，氨基酸脱羧酶抑制剂，和化学酶法合成(-)-鬼臼毒素)，3)使用高活性金属的新合成方法，4)过氧化氢的生物有机和合成化学(1，4-二烯的立体选择性双氧化和合成过氧化氢)，5)分子内铁磁耦合；6)理论和实验物理有机化学(硅氧烷研究、硝基和亚硝基加成)。带有质谱仪的气相色谱仪(GC-MS)使人们能够分离化合物混合物，并测量每一种化合物的分子质量。这些信息是确定分子式和/或新合成化合物的分子结构所需的基本信息之一。

This award from the Chemistry Research Instrumentation Program will assist the Department of Chemistry at the University of Nebraska in the purchase of a gas chromatograph with a mass spectral detector (GC-MS). This state-of-the-art bench top GC-MS is essential to meet current and future research needs of the Chemistry Department, primarily in the synethic groups in the Department. This instrument is essential for research in the department which includes the following areas: 1) New catalytic transition metal mediated carbocyclizations, 2) Bioorganic approaches to novel therapeutic agents, (phosphate inhibitors, amino acid decarboxylase inhibitors, and a chemoenzymatic approach to the (-)-podophyllotoxin),3) New synthetic methods using highly active metals, 4) Bioorganic and synthetic chemistry of hydroperoxides (steroselective dioxygenation of 1,4 dienes and synthesis of hydroperoxides), 5) Intramolecular ferromagnetic coupling in di- and trinitroxides, 6) Theoretical and experimental physical organic chemistry (siloxane research and nitro and nitroso additions). %%% The gas chromatograph with the mass spectral detector (GC-MS) allows one to separate a mixture of compounds and to measure the molecule weight of each of the individual compounds. This information is one of the essential pieces of information needed in order to determine the molecular formula and/or the molecular structure of newly synthesized compounds.