Synthesis of Vitamin K Models

这项来自有机动力学计划的拨款支持匹兹堡大学Paul Dowd教授继续研究维生素k依赖性羧化的新实验模型，以进一步揭示其在血液凝固复杂事件中的重要作用。将用同位素标记的氧来研究维生素K的氧合作用。随后将进行其他氧合和有关碱的性质以及其他强碱对活性的影响的研究。分子内模型、胶束、脂质体和模拟维生素K作用的膜区域的环境也将被探索。在这个项目中，保罗·多德博士将进行一系列广泛的氧合研究，使用标记的分子氧，揭示维生素K在血液凝固过程中起重要作用的复杂机制。不仅是一个新的实验模型用于维生素K的作用，而且它的环境是模拟维生素活性的膜区域。强碱对维生素K活性的影响是本研究的重要组成部分。

This grant from the Organic Dynamics Program supports the continuing work of Professor Paul Dowd at the University of Pittsburgh to study a new experimental model for the vitamin K-dependent carboxylation to further unravel its essential role in the complex events of blood clotting. The oxygenation of vitamin K will be studied using isotopically labeled oxygen. This will be followed by other oxygenations and investigations of the nature of the base(s) involved and of the effects of other strong bases on activity. Intramolecular models, micelles, liposomes and environments that mimic those of the membrane locale of the vitamin K action will also be explored. %%% In this project Dr. Paul Dowd will conduct an extensive set of oxygenation studies, using labeled molecular oxygen, to unravel the complex mechanism of blood clotting in which vitamin K plays an essential role. Not only is a new experimental model used for the action of vitamin K, but also its environment is modelled to mimic the membrane locale where the vitamin is active. The influence of strong bases on vitamin K's activity is an important part of this study.