Biochemistry and Regulation of Chlorophyll Synthesis

9304974 Timko叶绿素、氯化血红素及其衍生物在所有光合作用生物的能量吸收和传递过程中发挥着重要作用。该实验室分离并鉴定了三个核基因家族的成员，这些基因家族编码四吡咯生物合成途径的酶。我们希望实现三个目标。第一个目标是了解细胞如何以发育和细胞特有的方式调节各种四吡咯生物合成途径酶的协调形成。第二个目标是确定被子植物(豌豆)和裸子植物(松树)中编码原叶绿素还原酶基因表达调控机制的异同。为了实现这些目标，目前的研究将继续进行更多的努力，研究这些酶的形成和细胞内分布是如何调节的，控制它们的转录或转录后过程的性质随着细胞生理或环境的变化而变化。这些研究将为参与植物最基本过程之一的酶的结构、功能和表达提供重要的新信息。叶绿素及其类似分子在植物吸收光能并将其转化为食物和生物材料的能力中起着重要作用。研究人员已经分离并鉴定了三个基因家族，这些基因家族编码产生叶绿素和其他类似分子的酶。我们希望实现三个目标。第一个目标是了解细胞如何在植物的生命周期和植物的不同部分产生适量的酶。第二个目标是看看豌豆和松树中一种特定酶的基因控制有什么相似和不同之处。目前关于S这些酶的形成和细胞内分布如何受到不同过程调控的更多研究工作将继续进行。这些研究将为参与植物最基本过程之一的酶的结构、功能和表达提供重要的新信息。***

9304974 Timko Chlorophylls, hemes, and their derivatives play an important role in the energy absorption and transduction processes of all photosynthetic organisms. The laboratory has isolated and characterized members of three nuclear gene families that encode enzymes of the tetrapyrrole biosynthetic pathway. There are three objectives desired. The first objective is to understand how cells regulate the coordinate formation of the various tetrapyrrole biosynthetic pathway enzymes in a developmental and cell specific manner. The second objective is to define the similarities and differences in the regulatory mechanisms controlling the expression genes encoding protochlorophyllide reductase in angiosperms (pea) and gymnosperms (pine). In order to meet these objectives, more effort will continue on current studies examining how the formation and intracellular distribution of these enzymes are regulated, the nature of the transcriptional or post-transcriptional of processes that control them change in response to alterations in cell physiology or environment. These studies will provide important new information on the structure, function, and expression of enzymes involved in one of the most fundamental processes in plants. %%% Chlorophylls and similar molecules play an important role in the ability of plants to absorb light energy and transduce the energy into food and biomaterials. The researchers have isolated and characterized three gene families that code for the enzymes that produce chlorophyll and other similar molecules. There are three objectives desired. The first objective is to understand how cells produce the right amounts of the enzymes during the life of the plant and in different parts of the plant. The second objective is to see what is similar and different in the genetic control of one particular enzyme in peas and pine trees. More work on current studies examining how the formation and intracellular distribution of these enzyme s is regulated by different processes will continue. These studies will provide important new information on the structure, function, and expression of enzymes involved in one of the most fundamental processes in plants. ***