Workshop: "Developmental Instability: Origins and Evolutionary Implications;" Tempe, AZ; June 14-15, 1993

发育不稳定（DI）是指生物体不能正常发育，表现为身体异常、疾病和异常行为。DI的病因包括遗传和环境因素及其相互作用。在男性中，疾病包括唇裂、先天性心脏病、精神分裂症和染色体异常，以及接触致畸物，如酒精和异维甲酸。然而，尽管有广泛的理论解释，但尚不清楚发育稳态是如何被打破而产生异常表型的。该奖项支持一个名为“发育不稳定：其起源和进化意义”的研讨会。本次会议将讨论测量发育不稳定性的方法，不稳定性的遗传和发育起源，人类健康和表型变异，以及DI与总体种群生物学和进化的相关性。会议开辟了新的领域，具有很强的跨学科方法，加入了进化和发育生物学领域。%%% DI对种群生物学、环境生物学和人类健康具有深远的影响。据报道，在栖息地受到污染或以其他方式改变的生物种群中，以及在经历瓶颈和随后的近亲繁殖的生物种群中，DI增加。尽管缺乏这方面的知识，人工智能已经被用作决定物种是否濒危或人类是否处于危险之中的基础。

Developmental instability (DI) is the failure of an organism to develop normally, in ways ranging from physical anomalies and disease to abnormal behavior. The causes of DI include genetic and environmental factors and their interactions. In man, DIs include cleft lip, congenital heart disease, schizophrenia and chromosomal abnormalities as well as exposure to teratogens such as alcohol and isoretinoin. However, despite extensive theoretical explanations, it is not known how developmental homeostasis breaks down to produce abnormal phenotypes. This award supports a workshop titled "Developmental Instability: Its Origins and Evolutionary Significance". This conference will discuss ways to measure developmental instability, genetic and developmental origins of instability, human health and phenotypic variation, and DI's relevance to population biology and evolution in general. The coonference breaks new ground and has a strong interdisciplinary approach, joining the fields of evolutionary and developmental biology. %%% DI has far-reaching implications for population biology, environmental biology and human health. DI is reported to increase in populations of organisms whose habitats are polluted or otherwise altered, as well as in those experiencing bottlenecks and subsequent inbreeding. Despite this lack of knowledge, DI is already employed as the basis for decisions regarding whether species are endangered or humans are at risk.