Regulation of Streptomyces antibiotics by mia and abs

这项职业发展奖为在英国诺维奇的John Innes研究所休假期间的Champness博士提供部分支持。链霉菌以其合成大量次生代谢物(抗生素)的能力而闻名。除了它们的商业重要性外，链霉菌还因为其复杂的发育周期而令人感兴趣。在这个生命周期的过程中，抗生素的合成受到发育的调节。这项研究的目的是确定天蓝色链霉菌抗生素合成的全球遗传调控的各个方面。这项计划中的研究是基于钱普尼斯博士实验室最近发现的一组基因，这些基因调节抗生素基因的表达。主要目标是研究这些基因在全球范围内调节抗生素合成的机制。这种分子分析不仅有助于我们对微生物发育基因调控的理解，而且有助于生物技术。对天蓝色链霉菌调控的了解很有可能解释其他链霉菌和放线菌中的大部分抗生素调控，从而增加合理操纵商业上重要的代谢物生产的可能性，包括许多不断被发现的新代谢物。

This career advancement award provides partial support for Dr. Champness during a sabbatical leave at the John Innes Institute in Norwich, United Kingdom. Streptomycetes are well-known for their capacity to synthesize a vast repertoire of secondary metabolites (antibiotics). Besides their commercial importance, the Streptomyces are interesting for their complex developmental cycle. In the course of this life cycle, antibiotic synthesis is developmentally regulated. The objective of the research in this proposal is to define aspects of the global genetic regulation of Streptomyces coelicolor antibiotic synthesis. The research planned is based on a set of genes, recently discovered in Dr. Champness laboratory, which regulate the expression of antibiotic genes. The major goal is investigation of the mechanism by which these genes globally regulate antibiotic synthesis. %%% This molecular analysis promises to contribute not only to our understanding of microbial developmental gene regulation, but also to biotechnology. Understanding of S. coelicolor regulation is highly likely to explain much of antibiotic regulation in other Streptomycetes and Actinomycetes, and thus increase the potential for rational manipulation of production of commercially important metabolites including the many new metabolites that are continuously being discovered.