U.S.-Czech Joint Fund Research on DNA Structure and Interactions Using Electrochemical and Spectroscopic Techniques

这个由捷克科学院生物物理研究所Emil Palecek博士和Clarkson大学Petr Zuman博士共同发起的美国-捷克联合基金研究项目的主要目标是，是研究DNA的结构变化和与生物重要物质的相互作用。具体地说，研究人员将：1)制备DNA修饰的汞和石墨电极，2)研究固定在电极表面的DNA与蛋白质、插层药物、金属、以及抗癌物质与DNA在溶液中的相互作用，使用电化学和光谱方法进行比较。这个项目的结果应该有助于我们理解核酸与表面、蛋白质、小离子和药物的相互作用。这项在分子生物物理学方面的研究通过使美国和捷克的顶尖专家能够结合互补的人才和集合研究来实现推进科学知识的计划目标在双方都感兴趣和有能力的领域提供资源。根据既定的指导方针，该项目的资金通过设在布拉格的美国-捷克联合基金发放。

The primary objective of this US-Czech Joint Fund research project between Dr. Emil Palecek, Institute of Biophysics, Czech Academy of Sciences and Dr. Petr Zuman, Clarkson University, is to examine structural changes and interactions of DNA with biologically important substances. Specifically, the researchers will: 1) prepare DNA-modified mercury and graphite electrodes and 2) study the interactions of DNA anchored at the electrode surface with proteins, intercalating drugs, metals, and cancerostatic substances as compared with the DNA interactions in solution, using electrochemical and spectroscopic methods. The results of this project should contribute to our understanding of the interactions of nucleic acids with surfaces, proteins, small ions and drugs. This research in molecular biophysics fulfills the program objective of advancing scientific knowledge by enabling leading experts in the U.S. and Czech Republic to combine complementary talents and pool research resources in areas of strong mutual interest and competence. Funds for the project are awarded through the US-Czech Joint Fund, Prague, in accordance with established guidelines.