U.S.-France Cooperative Research: Studies of Kinetics of Iminyl Radical Cyclizations

9314294纽科姆这个为期两年的奖项支持韦恩州立大学的马丁·纽科姆和巴黎理工学院的S.Z.Zard在有机动力学方面的美法合作研究。他们的研究涉及对非常快的自由基反应的动力学测量。他们将研究稳定的碳和氮为中心的自由基，这是具有奇数个电子的中性原子基团。韦恩州立大学的研究小组开发了一种通用方法，用于研究广泛范围的自由基的动力学。这家法国集团将准备专门为韦恩州立大学开发的动力学方法设计的前体。他们将分离和鉴定反应产生的产品。然后，韦恩州小组将测量反应的速率常数，并制定自由基动力学标度。美国调查人员将物理有机化学方面的专业知识带到了这次合作中。法国研究人员在有机合成方面的专业知识补充了这一点。他们的共同工作将促进对这种新方法的理解，这种方法可以用于研究涉及自由基中间体的各种有机和生物反应。***

9314294 Newcomb This two-year award supports U.S.-France cooperative research in organic dynamics between Martin Newcomb of Wayne State University and S. Z. Zard of the Ecole Polytechnique. Their research involves kinetic measurements of very fast free radical reactions. They will study stabilized carbon-and nitrogen- centered radicals, which are neutral groups of atoms with an odd number of electrons. The Wayne State group has developed a general method for the kinetic study of a broad range of radicals. The French group will prepare precursors specifically designed for the kinetic method developed by Wayne State. They will isolate and characterize products resulting from the reactions. The Wayne State group will then measure the rate constants of the reactions and develop a scale of radical kinetics. The U.S. investigators bring to this collaboration expertise in physical organic chemistry. This is complemented by the French investigators' expertise in organic synthesis. Their joint work will advance understanding of this new method which could be used in studying a wide variety of organic and biological reactions that involve radical intermediates. ***