U.S.-New Zealand Cooperative Research: A Distribution-Moment Model of Cardiac Muscle

该奖项将部分支持圣路易斯华盛顿大学机械工程系的George Zahalak教授与新西兰奥克兰大学工程学院的Peter Hunter博士进行合作研究的旅费。该研究将侧重于修改现有的基于生物物理的骨骼肌模型，以应用于心脏力学。分布矩（DM）模型将被修改，以解释心肌的特殊力学。成功将产生一个基于生物物理交叉桥理论的数学上易于处理的模型，并将导致与纤维结构的当前信息的整合，从而产生一个包括激活，力学，能量学和代谢特征的心脏功能模型。Hunter博士在心脏生物力学方面的丰富经验将补充Zahalak博士在收缩动力学建模方面的背景。

9315743 Zahalak This award will partially support travel costs associated with the visit by Professor George Zahalak of the Department of Mechanical Engineering at Washington University, St. Louis, to conduct collaborative research with Dr. Peter Hunter of the School of Engineering at the University of Auckland in New Zealand. The research will focus on the modification of an existing biophysically-based model of skeletal muscle for application to cardiac mechanics. The Distribution-Moment (DM) Model will be modified in order to account for the specialized mechanics of cardiac muscle. Success will result in a mathematically tractable model based on biophysical cross-bridge theory, and should lead to integration with current information on fiber architecture resulting in a model for cardiac function including features of activation, mechanics, energetics and metabolism. Dr. Hunter's extensive experience in cardiac biomechanics will complement Dr. Zahalak's background in the modelling of contraction dynamics.