Acquisition of an 11.7 Tesla "500 MHz" NMR Spectrometer

9317886 Sanders申请部分资金（391780美元），用于购买配备11.7特斯拉磁铁（1H共振频率为500 MHz）的核磁共振（NMR）光谱仪，供多名研究人员使用。该文书费用的余额（362,500美元）将由凯斯西储大学和俄亥俄州摄制者行动基金的配套资金提供。这台机器将被安置在凯斯西储大学医学院（CWRU），将由五名研究人员使用，他们的研究兴趣如下：查尔斯·桑德斯，生理和生物物理系（建议使用35%的仪器）：利用定向样品核磁共振测定膜蛋白的结构。Michael Zagorski，化学系（25%）：淀粉样蛋白的结构研究。Thomas Gerken，儿科学系（20%）：o -链糖肽的结构研究。Masao ikeda saito，生理学和生物物理学系（10%）：髓过氧化物酶和肌红蛋白血红素位点的研究。博林格林州立大学Neocles Leontis(10%)：新型RNA和DNA基序的结构。拟议的仪器将极大地促进这些项目的短期和长期健康，因为它提供了CWRU目前无法获得的一些光谱能力。

9317886 Sanders Partial funding ($391,780) is requested for the acquisition of a nuclear magnetic resonance (NMR) spectrometer equipped with an 11.7 Tesla magnet (1H resonance frequency of 500 MHz) for use by multiple investigators. The balance of the cost of this instrument ($362,500) will be provided by matching funds from Case Western Reserve University and from the State of Ohio Regents' ACTION fund. This machine will be housed in the School of Medicine at Case Western Reserve University (CWRU) and will be used by a group of five investigators with research interests as follows: Charles Sanders, Dept. of Physiology and Biophysics (35% proposed instrument usage): Determination of the structures of membrane proteins using oriented sample NMR. Michael Zagorski, Dept. of Chemistry (25%): Structural studies of the amyloid proteins. Thomas Gerken, Dept. of Pediatrics (20%): Structural studies of O-linked glycopeptides. Masao Ikeda-Saito, Dept. of Physiology and Biophysics (10%): Studies of the heme sites of myeloperoxidase and myoglobin. Neocles Leontis, Bowling Green State University (10%): Structured of novel RNA and DNA motifs. The proposed instrumentation will dramatically facilitate both the short and long term health of these projects by providing access to a number of spectroscopic capabilities not currently available at CWRU.