Reactions and Sterochemistry of Organometallic Compounds Related to Asymmetric Synthesis and Catalytic Activity

9320668 Faller Yale University约翰·W·耶鲁大学Faller，耶鲁大学化学系，由无机，生物无机和有机化学计划支持，研究与不对称合成和催化有关的研究。利用金属配合物将开发出不对称和区域选择性合成的新方法。这些将包括一个有效的化学计量试剂的制备单烯丙醇的基础上的手性钼络合物，使用手性毒药，以简化制备催化剂的不对称合成，和手性亚砜的手性金属络合物的决议的发展。 与其镜像不相同的物体（例如左手手套与右手手套相比）被称为手性的。 许多药物和农业化学品是手性的，并且通常仅需要两个镜像分子中的一个。由于很难获得单一的镜像，因此生产这样的分子是当代化学的一个重要目标。在该项目中，解决“不对称合成”问题的新策略将应用于广泛的反应，并将开发这些重要分子的新的，更经济的制备方法。

9320668 Faller Yale University Dr. John W. Faller, Chemistry Department, Yale University, is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program for studies related to asymmetric synthesis and catalysis. New methods for asymmetric and regioselective syntheses will be developed using metal complexes. These will include an efficient stoichiometric reagent for the preparation of monallylic alcohols based on a chiral Mo complex, the use of chiral poisons to simplify the preparation of catalysts for asymmetric synthesis, and the development of chiral sulfoxides for the resolution of chiral metal complexes. An object which is not the same as its mirror image (e.g. a left compared to a right handed glove) is said to be chiral. Many pharmaceutical and agricultural chemicals are chiral and often only one of the two mirror image molecules is desired. Since it is difficult to obtain a single mirror image, the production of such molecules is an important goal in contemporary chemistry. In this project new strategies toward solving the problem of "asymmetric synthesis" will be applied to a broad range of reactions and new, more economic preparations of these important molecules will be developed.