RPG: Regulation of Neurogenesis Throughout the Lifespan

9408170布朗摘要这个项目的长期目标是了解如何将新的脑细胞添加到成年人的大脑中。在包括人类在内的哺乳动物中，被称为神经元的脑细胞只有在非常早期的发育过程中才会产生，由于受伤或疾病而失去的神经元无法被取代。在动物模型中，神经元被添加到已经存在的大脑回路中，这些回路对学习和产生用于交流的声音非常重要，解剖学和行为研究将解决促进大脑中新神经元添加的生物事件。了解神经元是如何被添加到大脑中的，可能会带来减轻神经疾病破坏性影响的治疗方法。

9408170 Brown ABSTRACT The long-term objectives of this project are to understand how new brain cells can be added to adult brains. In mammals including humans, brain cells called neurons are created only during very early development, and neurons that are lost as a result of injury or disease cannot be replaced. Using an animal model in which neurons are added to already-existing brain circuits which are important for learning and producing sounds used to communicate, anatomical and behavioral studies will address the biological events that promote the addition of new neurons to the brain. Understanding how neurons may be added to the brain could lead to therapies which would ameliorate the devastating effects of neurological disease.