The Use of Bioadhesive Microspheres to Treat Peptide Ulcer and the Development of a Novel Magnetic Device for the Analysis of Bioadhesive Interaction

本申请中提出的研究是关于开发一种新的磁性方法来研究单个聚合物微球与体外胃肠道组织活段之间的生物粘附。当附着组织以恒定速率分离时，粘附力将通过量化保持载铁微球静止所需的磁力来测量。给动物喂食装有放射性不透明材料的微球，其x射线成像将用于确定微球在体内与目标结构接触的位置和持续时间。该项目的一个重点将是将体外测定的粘附力与体内GI停留时间相关联。此外，将评估使用生物黏附微球来改善溃疡胃肠道组织的药物输送。* * *

9410387 Mathiowitz The research proposed in this application is concerned with the development of a new magnetic method to study bioadhesion between individual polymeric microspheres and living segments of gastrointestinal tissue, in vitro. The adhesion forces will be measured by quantifying the magnetic force required to hold an iron-loaded microsphere stationary, while the adherent tissue is separated at a constant rate. X-ray imaging of animals, which have been fed microspheres loaded with radio-opaque materials, will be used to determine the location and duration of contact of the microspheres with target structures, in vivo. A focus of the project will be to correlate adhesive forces determined in vitro with GI residence time in vivo. In addition, the use of bioadhesive microspheres to improve drug delivery to ulcerated GI tissue will be evaluated. ***