The Inverse Problem of Electrocardiography: New Computational Approaches, Numerical Simulations, and Experimental Verification

9410385因此，本申请中提出的研究涉及到最近发展起来的用于心电反问题的广义特征系统有限元技术，与其他现有方法相比，将被扩展，并通过与实验结果的比较来验证。初步结果表明，新的广义特征系统方法比已有的方法在具有前后球冠源的偏心球模型问题上具有更好的性能。这种广义特征系统技术将首先应用于非均匀偏心球问题，然后应用于具有真实人体心外膜电位的真实人体躯干模型。利用这两个模型，我们将检验电导率估算误差、各向异性特性误差和几何误差的影响，并与以前报道的方法进行比较。此外，这些技术将得到验证，并与离体兔心脏制剂的实验结果进行比较。计算问题，如改进的谱有限元，稳健性，准确性和效率将被考虑。***

9410385 Throne The research proposed in this application is concerned with a recently developed generalized eigensystem finite element technique for the inverse problem of electrocardiography will be extended, compared with other existing methods and validated by comparison with experimental results. Preliminary results indicate that the new generalized eigensystem method performs better than existing approaches on a previously reported eccentric spheres model problem with anterior and posterior spherical cap sources. This generalized eigensystem technique will first be applied to the inhomogeneous eccentric spheres problem and then to a realistic human torso model with realistic human epicardial potentials. With both models the effects of errors in estimating the conductivities, errors in the anisotropic properties, and geometrical errors will be examined and compared with previously reported methods. In addition, the techniques will be validated and compared with experimental results from an isolated rabbit heart preparation. Computational issues such as improved spectral finite elements, robustness, accuracy, and efficiency will be considered. ***