The Development, Characterization, and Utilization of Radical Anion Clock Reactions

有机动力学计划将资助Tanko教授的研究， 弗吉尼亚理工学院开发了一个明确而简单的 实验方法，可用于评估单个 电子转移（SET）途径，其中亲核试剂与 羰基。 发生快速不可逆反应的特定底物 在单电子还原后的重排将被构建并用作 自由基负离子时钟，用于测量事件的时间行为 在选定的一组有机反应中与SET相关。的 这项研究的意义在于它解决了以下基本问题： 有机化合物的反应性，并将导致更好的 了解如何自由基阴离子可以利用在合成有机 方法论 这项研究将设计和使用某些碳化合物， 结构使它们表现为一种内部分子钟 它可以监测电子在分子水平上的行为， 某些有机化合物发生反应。 增加了对 分子水平上事件的发生时间将产生重要的后果 用于生产具有商业重要性的新药和化学品

The Organic Dynamics program will fund the research of Professor Tanko at Virginia Polytechnic Institute to develop an unambiguous and simple experimental method which can be used to assess the importance of single electron transfer (SET) pathways in which nucleophiles react with carbonyl groups. Specific substrates which undergo rapid irreversible rearrangement upon one-electron reduction will be constructed and used as radical anion clocks to measure the temporal behavior of events associated with SET in a selected group of organic reactions. The significance of this research is that it addresses fundamental issues of the reactivity of oganic compounds and will lead to a better understanding of how radical anions can be exploited in synthetic organic methodology. This research will design and use certain carbon compounds whose architecture causes them to behave as a type of internal molecular clock which can monitor the way electrons behave at the molecular level when certain organic compounds react. Increased understanding about the timing of events at the molecular level will have important consequences for the production of new drugs and chemicals of commercial importance