Engineering Growth Factor/Receptor Processes

9414115 Lauffenburger这个项目正在进行研究，以更好地了解生长因子及其受体的动态，重点是表皮生长因子系统。这项工作的目的是操纵生长因子配体，作为改变贩运的一种手段。研究期间有三个具体目标：(1)操纵受体/配体和受体/细胞相互作用的参数，以检验先前构建的受体动力学模型；(2)研究配体通过模型组织的运输；(3)研究通过将工程配体和调节元件插入细胞系而创建的模型自分泌/旁分泌调节系统。对生长因子/受体动态和转运的了解可能会在伤口愈合、药物输送、基因治疗和组织再生方面带来改进。***

9414115 Lauffenburger This project is on research to better understand the dynamics of growth factors and their receptors, focusing on the epidermal growth factor system. The object of the work is to manipulate growth factor ligands as a means of altering trafficking. There are three specific aims for the period of study: (1) to manipulate parameters in receptor/ligand and receptor/cell interactions in order to test previously constructed models of receptor dynamics; (2) to investigate ligand transport through model tissues; and (3) to study model autocrine/paracrine regulatory systems created by inserting engineered ligands and regulatory elements into cell lines. The understanding of growth factor/receptor dynamics and trafficking could lead to improvements in wound healing, drug delivery, gene therapy, and tissue regeneration. ***