Developing Switchable Ligands to Control Gold Nanocluster Interfaces

该项目旨在通过开发能够进行受控分离和交换的可切换配体来解锁受保护的金纳米团簇的有前途的催化活性。该项目旨在详细了解纳米团簇的金硫醇盐界面如何影响其物理和化学性质。预期成果包括利用计算机辅助化学建模设计用于化学合成和生物测定的改进催化剂。这些催化剂在使用后应更容易回收，从而提高成本效益。它们还应提高生物传感器的准确性，最终可用于疾病的快速和早期检测。

This project aims to unlock the promising catalytic activity of protected gold nanoclusters by developing switchable ligands capable of undergoing controlled detachment and exchange. This project expects to provide a detailed understanding of how the gold thiolate interface of nanoclusters influences their physical and chemical properties. Expected outcomes include the design of improved catalysts for chemical synthesis and biological assays using computer aided chemical modelling. These catalysts should be easier to recover after use, which should improve cost-effectiveness. They should also improve the accuracy of biological sensors, which could ultimately be used for the rapid and early detection of diseases.