Bacterial membrane remodelling and the interaction with peptides

本项目旨在阐明革兰氏阴性外膜脂质重塑的基本机制，这在防止有害化合物和逃避宿主免疫防御方面都是至关重要的。第一次，细菌细胞代谢和膜重塑之间的复杂相互作用将通过系统药理学来定义，而精确的膜-肽相互作用将通过计算和生物物理方法来检查。新的知识将产生，以提高我们对细菌如何重塑其外膜以应对环境压力的理解。这将有利于未来设计急需的抗菌策略，包括针对细菌膜的产品和技术。

This project aims to elucidate the fundamental mechanism of lipid remodelling in Gram-negative outer membrane, which is critical both in preventing noxious compounds and evading host immune defence. For the first time, the complex interplays between bacterial cellular metabolism and membrane remodelling will be defined through systems pharmacology, and the precise membrane-peptide interaction will be examined by computational and biophysical approaches. Novel knowledge will be generated to improve our understanding on how bacteria remodel their outer membrane in response to environmental stress. This will benefit the future design of much-needed antimicrobial strategies including products and technologies to target bacterial membrane.