Preparation of Chiral, N-Substituted Oxyallyl Cations

有了这个奖项，合成有机项目支持了达特茅斯学院化学系的迈克尔·a·沃尔特斯博士的研究。沃尔特斯教授将把他的工作重点放在发展碳碳键形成的方法上。该研究将为制备手性合成化合物提供新的途径。本研究的重点是从α -环氨基酮中制备n -取代氧烯丙基阳离子，用于（4 + 3）环加成反应的中间体。手性助剂的使用将使光学活性化合物的合成成为可能。

With this award, the Synthetic Organic Program is supporting the research of Dr. Michael A. Walters of the Department of Chemistry at Dartmouth College. Professor Walters will focus his work on the development of methodology for the formation of carbon-carbon bonds. The research will lead to new ways for preparing chiral synthetic compounds. The focus of this research is the preparation of N-substituted oxyallyl cations from alpha-halo amino ketones for use as intermediates in (4 + 3) cycloaddition reactions. The use of chiral auxiliaries will enable the synthesis of optically active compounds.