Development of new asymmetric phosphenium salt catalysts, and its application to the construction of chiral tetra-substituted carbon.

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Phosphorus compounds are known as Lewis basic chemicals, however, cationic phosphines have Lewis acidic character. I focused on phosphenium salts, and I found that they worked as a Lewis acidic catalyst for hetero-Diels-Alder reaction. Although I synthesized a variety of chiral phosphenium salts, catalytic asymmetric reactions were not realized. Meanwhile, I found that one bis-urea compound, which was a synthetic intermediate of chiral phosphenium salt, formed a good complex with Ytterbium to catalyze highly reactive and highly stereoselective Diels-Alder reaction.