Microbial junk food: developing synthetic platforms for plastic degradation

本项目旨在建立食塑毛虫肠道微生物群微生物降解聚乙烯（PED）的遗传基础。它将把活性微生物PED基因转化为精心设计的合成微生物，用于高效、安全、大规模的PED。该项目将结合创新的功能性微生物遗传工具和合成生物学技术，与固体生物化学和生物信息学相结合，生产可翻译的合成平台，其中包含优化的关键基因，可以有效地去除PE废物。其结果将有可能将目前相对无效和昂贵的PE处置方法转变为适用于多个部门的灵活、成本效益和可持续的解决方案。

This project aims to establish the genetic basis of polyethelene biodegradation (PED) by microbes from the gut microbiome of plastic-eating caterpillars. It will transform the active microbial PED genes into carefully designed synthetic microbes for efficient, safe and large-scale PED. The project will combine innovative functional microbial genetic tools and synthetic biology techniques with solid biochemistry and bioinformatics to produce translatable synthetic platforms containing key genes optimised for efficient PE waste removal. The outcomes will have the potential to transform the relative ineffective and expensive current methods for PE disposal into flexible, cost-effective and sustainable solutions applicable to multiple sectors.