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Discovery of non-coding driver mutations and pathways in thousands of whole cancer genomes using gene regulatory and long-range chromatin interactions

Discovery of non-coding driver mutations and pathways in thousands of whole cancer genomes using gene regulatory and long-range chromatin interactions
利用基因调控和长程染色质相互作用发现数千个整个癌症基因组中的非编码驱动突变和通路
批准号：
389288
负责人：
Reimand Jüri
金额：
$65.76万
依托单位：
Ontario Institute for Cancer Research (Toronto, Ontario)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2018
资助国家：
加拿大
项目状态：
已结题
起止时间：
2018-09-01 至 2022-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=389288&lang=en
关键词：
Biomarker Discovery Cancer Driver Genes Chromatin Interactions Epigenomics Functional Validation Meta-Analysis Pan-Cancer Pathway And Network Analysis Variant Interpretation Whole Genome Sequencing

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中文摘要
翻译
癌症是一种遗传性疾病，但大多数癌症不是遗传的，而是由个体DNA随时间的随机突变引起的。虽然大多数这样的突变是无害的，但少数被称为癌症驱动突变（driver）的突变会影响关键基因
英文摘要
Cancer is a genetic disease however most cancers are not inherited but are instead caused by random mutations in individuals' DNA over time. While most such mutations are harmless, a minority called cancer driver mutations (drivers) affect critical genes
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