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Implication of early embryonic epigenetic dysregulation in fetal alcohol spectrum disorders-associated outcomes

Implication of early embryonic epigenetic dysregulation in fetal alcohol spectrum disorders-associated outcomes
早期胚胎表观遗传失调对胎儿酒精谱系障碍相关结果的影响
批准号:
435858
负责人:
McGraw Serge
金额:
$60.19万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2020
资助国家:
加拿大
项目状态:
未结题
起止时间:
2020-10-01 至 2025-10-01

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中文摘要
翻译
胎儿酒精谱系障碍(FASD)是一种广泛存在但在加拿大所有社会经济群体中都未得到充分认识的疾病,其原因是孕妇在怀孕期间饮酒。FASD症状的严重程度和表现形式差异很大
英文摘要
Fetal alcohol spectrum disorders (FASD), a widespread yet under-recognized condition found in all socioeconomic groups in Canada, results from maternal consumption of alcohol during pregnancy. The severity and presentation of FASD symptoms are highly vari
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会议论文
Germline DNMT3A loss-of-function alters PRC2-dependent H3K27me3 deposition and leads to neuronal impairments.
Impact of early embryonic alcohol exposure on DNA methylation programming in the etiology of fetal alcohol spectrum disorders.
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