Investigations of Autonomous Yeast Oscillations

9522274 Hjortso本项目是研究S.酿酒酵母在恒化器中在葡萄糖限制下生长。 虽然已经提出了能够模拟所观察到的行为的生物和数学模型，但这种振荡的偶然性质尚不清楚。 一个先前开发的年龄结构模型将用于本研究。 这个模型可以用分裂年龄来解释振荡的开始。 同时进行的实验和模型优化计划将用于提高对生物过程改进最终目标的理解。 ***

9522274 Hjortso This project is on research to study autonomous oscillations of S. cerevisiae growing in a chemostat under glucose limitation. The casual nature of such oscillations is unclear although biological and mathematical models able to simulate the observed behavior have been proposed. A previously developed age structured model will be used in this research. This model can use division age to explain the onset of oscillations. A simultaneous program of experimentation and model refinement will be used to increase understanding with the ultimate goal of bioprocess improvement. ***