STTR: Analytical Microseparations with Nuclear Magnetic Resonance Detection

小行星9523220 本研究旨在扩展现有的核磁共振（NMR）检测池模型，以获得两个数量级的灵敏度提高。 目前的核磁共振波谱仪由于灵敏度相对较差，作为微量分离的检测器应用有限。 新的细胞将采用专门设计的RF微线圈，将用于流动分析分离，同时保留完整的NMR能力，用于结构测定。 这使得细胞能够分析化学物质的质量有限和体积有限的样品。 本研究的总体目标是创建新一代优化的纳升体积NMR检测池，用于液相色谱和毛细管电泳微分离研究的商业化。

9523220 Peck This research is to extend current models of nuclear magnetic resonance (NMR) detection cells to obtain a two order of magnitude improvement in sensitivity. The current NMR spectroscope has limited application as a detector for microseparations because of its relatively poor sensitivity. The new cells will employ specially designed RF microcoils that will be used in flowing analytical separation while retaining the full NMR capability for structural determination. This enables the cells to analyze mass-limited and volume-limited samples of chemical species. The overall goal of this research is to create a new generation of optimized nanoliter volume NMR detection cells for commercialization for liquid chromatography and capillary electrophoresis microseparation studies.