Cell-Surface Glycoconjugates II

本研究的重点是综合方法学的发展 用氨基酸作为合成细胞表面蛋白的起始原料， 碳水化合物，以及碳水化合物的机制抑制剂 加工酶 靶点包括氮杂糖、吲嗪和 吡咯里西啶生物碱。 目前的方法将被扩展到生产 岩藻脂生物合成抑制剂和复合生物碱， 石蒜碱 此外，席夫碱将用于生产 氮杂-C-糖苷、UDP-半乳糖和GDP-岩藻糖类似物， 糖基转移酶抑制剂。 席夫碱也将用于 合成光学纯的C2-对称手性配体， 在不对称、金属催化的环氧化中的应用潜力。 与此 更新奖，合成有机计划是支持研究 罗宾·L博士波尔特是牛津大学化学系的教授， 亚利桑那 波尔特教授将把他的研究重点放在合成 糖苷酶和糖转移酶抑制剂。 这些抑制剂 对研究细胞表面碳水化合物的生物合成很重要。

The focus of this research is the development of synthetic methodology using amino acids as starting materials for the synthesis of cell-surface carbohydrates, and the mechanism-based inhibitors of carbohydrate processing enzymes. Targets include aza-sugars, indolizidine and pyrrolizidine alkaloids. Current methods will be extended to produce fucolipid biosynthesis inhibitors and complex alkaloids such as lycoricidine. Also, Schiff bases will be used to produce aza-C-glycoside, UDP-galactose and GDP-fucose analogs to serve as glycosyltransferase inhibitors. Schiff bases will also be used to synthesize optically pure C2-symmetric chiral ligands, ligands that have potential for use in asymmetric, metal catalyzed epoxidations. With this renewal award, the Synthetic Organic Program is supporting the research of Dr. Robin L. Polt of the Department of Chemistry at the University of Arizona. Professor Polt will focus his research on the synthesis of glycosidase and glycotransferase inhibitors. These inhibitors are important for the study of the biosynthesis of cell-surface carbohydrates.