Synthesis and Chemistry of Novel Fluorocarbons

这项研究的重点是合成和研究一系列高度氟化的目标分子的化学，所有这些分子的骨架都有12个或更少的碳原子。从头算量子力学计算将被用作实验设计的指南和解释实验结果的辅助工具。有了这一续期奖，合成有机计划将支持达特茅斯学院化学系的大卫·M·莱马尔博士的研究。莱马尔教授将把他的工作重点放在一系列高氟化合物的合成和化学研究上。有机分子中的氢被氟取代后，在性质和化学行为上都会产生巨大的差异。因此，氟碳化学具有重要的商业意义。

The focus of this research entails the synthesis and investigation of the chemistry of an array of highly fluorinated target molecules, all of which have skeletons of twelve or fewer carbon atoms. Ab initio quantum mechanical calculations will be employed as both a guide to the design of experiments and as an aid in the interpretation of experimental results. With this renewal award, the Synthetic Organic Program is supporting the research of Dr. David M. Lemal of the Department of Chemistry at Dartmouth College. Professor Lemal will focus his work on the synthesis and investigation of the chemistry of an array of highly fluorinated compounds. Replacement of the hydrogens in organic molecules by fluorine results in dramatic differences in both properties and chemical behavior. As a result, fluorocarbon chemistry has great commercial importance.