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New Catalytic Chemistry: Capturing reactive and unreactive functional groups for novel heterocycle synthesis

新催化化学：捕获反应性和非反应性官能团以合成新型杂环

基本信息

批准号：
EP/G007519/2
负责人：
Michael Greaney
金额：
$ 80.99万
依托单位：
University of Manchester
依托单位国家：
英国
项目类别：
Fellowship
财政年份：
2011
资助国家：
英国
起止时间：
2011 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FG007519%2F2
关键词：
New Catalytic Chemistry Capturing reactive

项目摘要

The proposed research looks to create new ways of making molecules using catalysts - catalytic chemistry. A catalyst is something added in very small amounts to a reaction that will make it faster, and they play a very important in modern chemistry. Up to 90% of chemically produced materials have used a catalyst in their production - the enzymes in washing powder are a type of biological catalyst that helps break down organic stains on clothes, for example. The catalytic converter in a car contains precious metal catalysts that help convert harmful nitrogen monoxide fumes into harmless nitrogen gas.Catalysts can dramatically accelerate chemical reactions, to the extent where some impossibly slow processes become highly efficient when performed under catalytic conditions. The trick is matching up the right catalyst with the right chemical reaction. This research proposal will look at the chemical reactions that are used to make a class of molecule called heterocycles. Heterocyclic compounds have enormous importance in our society: DNA, sugars, proteins, the molecules of nature, drugs, insecticides and vitamins represent just some of the classes of heterocycle essential to the way we live our lives. As a result, the discovery of new and improved ways to synthesise new and improved heterocycles is at the forefront of modern chemistry research. The successful research project will produce new molecules using catalytic processes that are quicker, cheaper and more environmentally friendly than existing methods. We will take these reactions and apply them to the production of new heterocycles for application in medicine, engineering and agriculture.

这项拟议中的研究旨在创造使用催化剂制造分子的新方法-催化化学。催化剂是添加到反应中的非常少量的东西，它会使反应更快，它们在现代化学中起着非常重要的作用。高达90%的化学生产材料在生产过程中使用了催化剂-例如，洗衣粉中的酶是一种生物催化剂，有助于分解衣服上的有机污渍。汽车中的催化转化器含有贵金属催化剂，可帮助将有害的一氧化氮烟雾转化为无害的氮气。催化剂可以显著加速化学反应，在催化条件下，某些缓慢得不可思议的过程变得非常高效。关键在于将正确的催化剂与正确的化学反应相匹配。这项研究计划将着眼于用于制造一类称为杂环的分子的化学反应。杂环化合物在我们的社会中具有巨大的重要性：DNA，糖，蛋白质，自然分子，药物，杀虫剂和维生素只是我们生活方式中必不可少的杂环的一部分。因此，发现新的和改进的方法来合成新的和改进的杂环是现代化学研究的前沿。成功的研究项目将使用比现有方法更快，更便宜和更环保的催化过程来生产新分子。我们将采取这些反应，并将其应用于生产新的杂环化合物，用于医学，工程和农业。