Japan JSPS Program: In Vitro Evaluation of a Phospholipid Polymer for Medical Device Applications: International Research Fellow Award

9600325 Williams该奖项为日本东京医科和牙科大学医学和牙科工程研究所的Betsy Newton-Williams博士提供为期12个月的日本科学促进会（JSPS）博士后奖学金。Newton-Williams博士将与有机材料部主任Nobuo Nakabayashi博士合作开展一项名为“用于医疗器械应用的磷脂聚合物的体外评估”的研究项目。拟议的研究将评估（甲基丙烯酰氧乙基磷酸胆碱）MPC共聚物作为表面增强剂的使用，以提高植入物的性能，抑制细菌粘附和细胞附着。由于皮肤细胞附着在植入物上以及植入物周围过度的组织生长，经皮植入装置的成功受到限制。当细菌附着在植入物表面并通过皮肤和植入物之间的区域进入下层组织时，植入物也会因感染而失效。本研究的目的是通过MPC共聚物的掺入和防止细胞和细菌附着来提高种植体的性能。将MPC聚合物结合到块状材料表面的不同方法将被检查。在研究过程中，将评估MPC的分布和材料表面MPC的完整性，以及体外蛋白质吸附、细胞附着和细菌粘附。* * *

9600325 Williams This award supports a 12 month Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowship for Dr. Betsy Newton-Williams at the Institute of Medical and Dental Engineering, Tokyo Medical and Dental University, Tokyo, Japan. Dr. Newton-Williams will work with Dr. Nobuo Nakabayashi, Director of the Division of Organic Materials, on a research project entitled "In Vitro Evaluation of a Phospholipid Polymer for Medical Device Applications." The proposed research will evaluate the use of (methacryloyloxyethyl phosphorylcholine) MPC copolymers as a surface enhancement to improve the performance of implants and inhibiting bacterial adhesion and cell attachment. The success of percutaneous implant devices has been limited due to attachment of the skin cells to the implant and excessive tissue growth around the implant. The implants also fail due to infection when bacteria adhere to the implant surface and gain access to the underlying tissue through the area between the skin and the implant. The objective of this research is to improve implant performance through the incorporation of an MPC copolymer and the prevention of cell and bacterial attachment. Different methods of incorporating MPC polymers onto the surface of the bulk material will be examined. The distribution of MPC and the integrity of the MPC on the material surface will be evaluated during research, as well as in vitro protein adsorption, cellular attachment, and bacterial adherence. ***