Replacement of Induced Mutant Resource Facilities

位于缅因州巴尔港的杰克逊实验室（TJL）是ARI基金的接受者，用于替换诱导突变资源（IMR）的现有研究空间。 IMR成立于1992年，是转基因、靶向突变和化学诱导突变小鼠的冷冻保存和分发的国家中心。 IMR目前在不同设施中提供的服务包括：进口健康状况不明的小鼠、冷冻保存胚胎以及需要特殊健康保障或育种模式的小鼠的维持和近亲繁殖。 然而，随着快速增长，这些过程的整合对于IMR的成功至关重要，IMR对所有领域的生物研究的开展越来越重要，并且在现有条件下无法实现。 这些设施的配置严重限制了质量控制功能，现在需要单独的、重复的胚胎移植设施和动物群。 缺乏足够的空间阻碍了动物实验室接受品系作为冷冻保存的胚胎或配子，也阻碍了开发和实施动物再衍生的新方法。 该项目是TJL为IMR建造永久设施的更大努力的一部分。 具体来说，NSF的资金将用于替换SPF和冷冻保存设施的研究空间。整合这些功能将允许TJL只接受用于冷冻保存的菌株，增加IMR可以保存的菌株数量，同时保持储存库的成本可控。作为实验室的研究和教育发展战略计划的一个重要组成部分，更换结构将促进在发展生物学，分子遗传学和神经遗传学和行为建设方案的招聘工作。 研究将得到加强，以及先进的培训计划，研究人员有机会获得IMR的诱导突变模型的聚宝盆。 该项目将确保这一科学保护区的可行性。

The Jackson Laboratory (TJL), located in Bar Harbor, Maine, is the recipient of ARI funds for the replacement of existing research space for the Induced Mutant Resource (IMR). Established in 1992, the IMR is a national center for the cryopreservation and distribution of transgenic, targeted mutant, and chemically induced mutant mice. Current services of the IMR that occur in separate facilities include: importation of mice of unknown health status, cryopreservation of embryos, and the maintenence and inbreeding of mice which require unusual health safeguards or breeding paradigms. However with rapid growth, the integration of these processes are imperative to the success of the IMR which is increasingly important to the conduct of biological research in all areas, and cannot be achieved under existing conditions. The configuration of the facilities presents serious limitations to quality control functions that now require separate, duplicative embryo transfer facilities and animal colonies. The lack of adequate space hinders the IRM from accepting strains for preservation as cryopreserved embryos or gametes, and from developing and implementing new methods for rederiving animals. This project is part of a larger effort of TJL to construct a permanent facility for the IMR. Specifically, NSF funds will be used to replace research space for the SPF and Cryopreservation facilities. Consolidating these functions will allow the TJL to accept strains for cryopreservation only, increasing the number of strains the IMR can preserve, while keeping costs of the repository manageable. As an important component of the Laboratory's strategic plans for research and educational growth, the replacement structure will facilitate recruitment efforts in building programs in developmental biology, molecular genetics and neurogenetics and behavior. Research will be enhanced as well as advanced training programs where research personnel have access to the IMR's cornucopia of induced mutant models. This project will ensure the viability of this scientific reserve.