U.S.-Mexico Cooperative Research: Glycosylation with C(1) Metalated Glycosides

小行星9602925 这个美洲计划奖将资助亚利桑那大学图森分校的理查德·格拉斯博士和I.P.N.的尤西比奥·朱里斯蒂博士之间的一个合作研究项目，墨西哥 本研究旨在开发一种在温和和中性氧化条件下通过生成糖氧碳正离子合成糖苷的新方法。将研究使用该反应形成糖苷、核苷和C-糖苷，以确定糖苷和相关化合物的构象行为。 模型化合物将用于系统研究该方法的可行性，以及对相邻取代基的耐受性。 这是一个相当大的当前研究兴趣的领域，如果成功的话，该研究可能会产生有用的方法，糖和核苷化学的潜在应用，以开发新的治疗药物。 对于该项目，铁络合物的合成及其氧化还原化学将在亚利桑那州进行，其构象分析和Fp糖的选定前体的合成将在墨西哥进行。 ***

9602925 Glass This Americas Program award will fund a collaborative research project between Drs. Richard Glass, University of Arizona, Tucson, and Eusebio Juaristi, I.P.N., Mexico. The research aims to develop new methods for synthesis of glycosides by generating sugar oxocarbenium ions under mild and neutral oxidizing conditions. The use of this reaction for the formation of glycosides, nucleosides, and C- glycosides will be investigated to ascertain the conformational behavior of the glycosides and related compounds. Model compounds will be used in a systematic study of the feasibility of the method, and on the tolerance to neighboring substituents. This is an area of considerable current research interest and, if successful, the study may generate useful methods for saccharide and nucleoside chemistry of potential application to the development of new therapeutic agents. For this project, the synthesis of the iron complexes and their redox chemistry will be done in Arizona, and their conformational analysis and synthesis of selected precursors of the Fp sugars will be carried out in Mexico. ***