U.S.-France Cooperative Research: Molecular Mechanism of Homologous Pairing and DNA Strand Exchange

这三年的美国奖-法国基因重组合作研究 包括加州大学戴维斯分校的斯蒂芬·科瓦尔奇科夫斯基，阿兰·尼古拉斯， 法国巴黎居里研究所的玛丽·杜特雷和弗朗西斯法布尔。 该奖项 为Kowalczykowski博士和一名毕业生提供旅行支持和生活费用 学生. 他们研究的目的是研究同源配对， 随后的DNA链交换。 这一过程是由一类独特的 以来自大肠杆菌的原型RecA蛋白和新的RecA蛋白为代表的蛋白质， 来自酿酒酵母的Rad 51蛋白。 美国调查人员将此 在重组的物理和生物化学方面的合作专长。 这是 再加上法国在分子遗传学方面的专业知识。 该项目将推进 对基因重组所涉及的生物过程有基本的了解， 包括导致有害的基因组重排的异常过程。

This three-year award for U.S.-France cooperative research on genetic recombination involves Stephen Kowalczykowski of the University of California at Davis, Alain Nicolas, Marie Dutreix, and Francis Fabre of the Institut Curie in Paris, France. The award provides travel support and living expenses to Dr. Kowalczykowski and a graduate student. The objective of their research is to investigate homologous pairing and subsequent exchange of DNA strands. This process is mediated by a unique class of proteins represented by the prototypic RecA protein from Escherichia coli and by the new Rad51 protein from Saccharomyces cerevisiae. The U.S. investigator brings to this collaboration expertise in the physical and biochemical aspects of recombination. This is complemented by French expertise in molecular genetics. The project will advance fundamental understanding of the biological processes involved in genetic recombination, including aberrant processes that lead to deleterious genomic rearrangements.