U.S.-Korea Cooperative Research on Stereochemical Studies of Malonate Metabolism

该奖项支持华盛顿大学的Heinz Floss博士和韩国首尔延世大学的Yu Sam Kim博士为期三年的合作研究项目“丙二酸盐代谢的立体化学研究”。该项目的目标是1)确定选定物种的丙二酸脱羧酶对丙二酸脱羧的立体化学过程，2)确定甲基丙二酸活化的立体特异性（如果有的话）。金博士在韩国的研究小组长期对丙二酸盐及其衍生物在植物和微生物中的代谢和生理作用感兴趣，并就此主题进行了广泛的研究。Heinz博士的研究小组在酶催化反应的立体化学分析方面拥有丰富的经验，并开发了以丙二酸盐为底物的反应分析方法。这个项目将把这些研究小组聚集在一起，研究一些涉及丙二酸酯或其衍生物转化的酶反应的立体过程。这项研究将有助于提高对酶反应机制的理解。＊＊＊

Floss 9604888 This award supports a three-year collaborative research project between Dr. Heinz Floss of the University of Washington and Dr. Yu Sam Kim of Yonsei University in Seoul, Korea on "Stereochemical Studies of Malonate Metabolism." The goals of the project are 1) to determine the stereochemical course of malonate decarboxylation by the malonate decarboxylases from selected species and 2) to determine the stereospecificities, if any, of methylmalonate activation. Dr. Kim's research group in Korea has a long-standing interest in the metabolism and physiological role of malonate and its derivatives in plants and microorganisms and has done extensive research on this subject. Dr. Heinz' research group has extensive experience in the stereochemical analysis of enzyme-catalyzed reactions and has developed methods for the analysis of reactions involving malonate as substrate. This project will bring these research groups together to study the steric course of a number of enzyme reactions involving transformations of malonate or its derivatives. The study should lead to improved understanding of enzyme reaction mechanisms. ***